‘Of course, that's about appropriate. I search for a Bodily idea of biological techniques in a very bottom-up way. I believe you could possibly distinguish three traces of investigate in my group at this time. The very first problems chromosome composition: how do you get yourself a metre-very long DNA polymer folded and organised in this kind of microscopic cell? We've got designed visualisation procedures that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) to be able to Create up chromosomes.

You often become involved in conversations about science and faith. You have got also prepared a number of guides on the topic. Don’t you think that eventually We'll know all the things and that God’s job will likely be over?

Dynamics of initiation, termination and reinitiation of DNA translocation because of the motor protein EcoR124I

Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.

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Microbiology has only existed for a century, because we started to research micro-organisms a lot more significantly. I believed nanobiology was an acceptable expression, because all molecular biological relevant interactions take place at the nanoscale: a protein is a couple of nanometres in dimension, DNA is 2 nm thick.’

All parameters have been the exact same for every panel in this video, except for the Preliminary placement on the 6hb rod (demonstrated in blue) over the nanopore. Simulations that terminated early due to translocation from the rod with the pore are marked by a grey track record.

2011, very first in ceesdekker.net vitro measurements of transport throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the system of homology recognition in DNA homologous recombination

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Quite cool, but that wasn’t actually wherever my interest lay. I wished to pioneer And that i experienced the feeling which was now not feasible, since the most attention-grabbing fundamental insights had previously been uncovered. But my industry had produced quite a few exciting new resources to measure particular person molecules. I made a decision that I desired to implement this to biology, to have a look at it from the Actual physical point of view.’

An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of very first logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA repair service enzymes with AFM

2008, 1st observation of protein-coated DNA translocation by means of nanopores; resolved the origin of your electrophoretic pressure on DNA in nanopores; identified a substantial velocity increase of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid

2013, controlled shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes